Friday, January 3, 2020

Scientific Abstract Smoking And Alcohol Consumption

Scientific Abstract Smoking and alcohol consumption are well established as risk factors regarding oral cancer incidence. Previous studies indicated a possible additive effect of alcohol and tobacco on oral cancer risk, yet no observational studies in the last 25 years have accounted for their interaction. This study was initiated to elucidate smoking and drinking single, joint and interactive effects on oral cancer incidence. A hospital-based observational study collected patient data using questionnaires from 4 Sao Paulo, Brazil, hospitals, November 1998 to December 2008. Patients were recruited based on having squamous cell carcinoma of the oral cavity or oropharynx. Using 1,144 cases and 1,661 controls, age, gender and schooling level effects were assessed using logistic regression, and variables with significant odds ratios (ORs) for oral cancer were included in the models as confounders. Individual and joint effects of smoking and drinking on oral cancer risk were also assessed by logistic regress ion using ORs based on two types of analyses (models). In the first, exposure variables drinking and smoking were treated as binary (never, reference group; ever, risk group), and in the second categorized into three levels (never, reference group; level-1 and level-2, risk groups). 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